Be the clinician and diagnose aHUS

The previous blog illustrates the difficulty of diagnosing aHUS.
From the basic information about some patients have a go at diagnosing whether following have
A. aHUS ,
B. A secondary form of aHUS
C . “typical” HUS.

  1. 7 year old with TMA and HUS after receiving chemotherapy for her cancer
  2. 48 year old with severe high blood pressure and a complaint that they did not have money to further their medication
  3. 6 year old with TMA and HUS
  4. 9 year old with TMA and HUS during severe gallstone pancreatitis
  5. 33 year old with TMA after his stem cell transplant
  6. 11 year old with history of TMA and HUS and kidney loss in her native kidneys and kidney transplant
  7. 21 year old with TMA , HUS a butterfly rash , joint pain , joint swelling and an abnormal autoimmune test
  8. 3 year old with TMA and HUS after he drank unpasteurised apple cider.
  9. 22 female year old with symptoms of nausea , diarrhoea and acute kidney failure during a localised outbreak of e coli  poisoning and  with a family history of kidney failure.
  10. 29 year old with TMA, difficulty speaking and low levels of ADAMTS 13

Acknowledgements to Dr Carla Nester of the University of Iowa for the above case studies 1 to 8 presented at the 2014 aHUS Conference.
See below for decisions made :
Cases 3 , 6 and 9  had aHUS – no other cause of TMA in the first instance  and history of TMA /Kidney Disease  in the second case and  third case
Case 8 had typical HUS
Case 10 had TTP
The remainder of the cases had a secondary form of aHUS
Acknowledgement to Campistol Group for the featured image  ( click here for article)

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