aHUS transplants simplified

Article No. 387

13 October 2020

This website has featured several articles* about the topic of  aHUS Transplants and their need for  eculizumab support. These articles have provided some of the  answers about whether  eculizumab is needed to avoid a re-onset of aHUS when triggered by the transplant, and whether eculizumab should be given before or after the transplant operation.

We know now that not all transplants need eculizumab, but , if they do, they should be supported before the operation rather than after it for the bests results i.e. the quality of kidney  function and longevity of the kidney graft. Information is also now emerging about whether, and when, eculizumab treatment can be withdrawn. It  can in some cases, at some point in time.

This summer an article was published by Dr Anuja Java about managing aHUS transplants (click HERE to see the abstract). It was accompanied by an infographic which summarises , in a simple way, what has been learned about aHUS transplants in the past few years. The original has been cropped and enlarged for website resolution purposes and is presented below in five images

– overview of aHUS

– pre-transplant evaluation

– donor selection and peri-operative management

-recurrence risk evaluation –

duration of therapy.

 

 

 

 

 

The original complete infographic

*Previous website articles on aHUS Transplants

THAT AHUS TRANSPLANT QUESTION

…of the delay to rescue. The French Group provided a transplant strategy for aHUS kidney transplant decisions in France which became the basis for many future aHUS patients transplants around…

AHUS KIDNEY TRANSPLANT-MORE INSIGHTS

…“Is there a significant difference in outcome between having a complement inhibitor before or after a kidney transplant?” Following this study it is known that: Transplant can trigger aHUS, but…

TRANSPLANT AND AHUS RISKS

…in an Orphanet Journal article, which can be seen by clicking here. At the top of the alliance list was knowing what the outcomes were of transplants with or without…

TRANSPLANTS, AHUS AND ECULIZUMAB

…dialysis patients, who have already experience kidney loss from an aHUS onset are rightly concerned about whether not getting prophylactic eculizumab has a detrimental effect on transplant outcomes. Transplant outcomes…

ERKNET: AHUS AND TRANSPLANTS

…5.6 per 1000 , 50% mortality Post Transplant TMA incidents could be recurrence or “de novo” ( although diagnosis in native kidney loss could have been missed). Conditions of transplant

TRANSPLANTATION AND AHUS – A TOP TOPIC

Transplantation of aHUS dialysis patients is a priority and top topic for the aHUS alliance. Transplantation of those with aHUS has been a challenge, not just clinically because of the…

AHUS TRANSPLANTS-ABSTRACT VIDEO

The aHUS alliance affiliates put the question: Is there a significant difference in outcome between having a complement inhibitor before or after a kidney transplant? at the top of its