A kidney transplant used to be contraindicated for those predisposed to aHUS. Although it could have been successful for some depending on their genetic susceptibility, most would lose their kidney graft. Often very quickly. When complement inhibitor eculizumab became available, it was possible for those most at risk to have a transplant.
A kidney transplant can trigger aHUS, but cannot cure it, Ellen.
It can replace some kidney function, much more than is available to those on kidney dialysis but not as much as having two fully functioning kidneys. But more than sufficient to have a full life.
How much kidney function becomes available depends on factors other than aHUS . But what is known is that overall more function is achieved in those whose aHUS transplant was supported by eculizumab ( prophylactic) from the outset of the operation, than for those who got eculizumab as a rescue therapy when aHUS was triggered following the transplant.
The research that led to the above conclusion was stimulated by aHUS questions which produced the Global aHUS Patients’ Research Agenda.
For a kidney transplant to be part of a cure in some aHUS people, their liver would need to be replaced too. It is the liver that often produces the mutated Complement components that are the cause of aHUS.
How to resolve the mutations without replacing the liver is another question.
Article No. 493
Here are some past articles on the transplant question:
Article No. 387 13 October 2020 This website has featured several articles* about the topic of aHUS Transplants and their need for eculizumab support. These articles have provided some of…CONTINUE READINGaHUS transplants simplified
Article No. 378 22 September 2020 aHUS and kidney transplants is an important research topic for aHUS patients with end stage renal failure. aHUS alliance Global Action has featured several…CONTINUE READINGaHUS Kidney Transplant-More insights
Article No. 330 8 March 2020 Although it is becoming less of an issue for many these days because the advent of eculizumab/ Ravulizumab saves them from it, but…CONTINUE READINGThat aHUS transplant question
The alliance has frequently featured articles about kidney transplants for those with aHUS. It was its top topic identified as a priority for research that matters to aHUS patients ,…CONTINUE READINGTransplants, aHUS and eculizumab
The aHUS alliance affiliates put the question: Is there a significant difference in outcome between having a complement inhibitor before or after a kidney transplant? at the top of its…CONTINUE READINGaHUS Transplants-Abstract Video
These days a kidney transplant may not feature much in the thoughts of new onset aHUS patients, most of them can be saved from a life of chronic end stage…CONTINUE READINGTransplant research answers that matter to aHUS patients
ERKNET’s website hosts a programme of webinars ( live talks over the internet) about Rare Renal Diseases . The talk today was given by Professor Marius Miglinas , Head of…CONTINUE READINGERKNET: aHUS and transplants
The aHUS Alliance was invited by the aHUS Registry Scientific Board to say what matters most to patients in aHUS research. The alliance’s response to that invitation is well documented…CONTINUE READING
Transplantation of aHUS dialysis patients is a priority and top topic for the aHUS alliance. Transplantation of those with aHUS has been a challenge, not just clinically because of the…CONTINUE READINGTransplantation and aHUS – a top topic
Anyone, who has been involved in aHUS patient advocacy for some time, will be aware of the special place that those patients, whose aHUS has left them with chronic kidney…CONTINUE READING